Special Precautions:
Not for relief of acute asthma symptoms. Consider increasing corticosteroid therapy in sudden & progressive deterioration of asthma control. Avoid abrupt w/drawal. Possible development of pneumonia in patients w/ COPD. Active or quiescent pulmonary TB, thyrotoxicosis, preexisting CV disease. Patients predisposed to low serum K levels. Systemic effects (including Cushing's syndrome, Cushingoid features, adrenal suppression, growth retardation in childn & adolescents, decrease in bone mineral density, cataract, glaucoma & central serous chorioretinopathy) may occur at high doses for prolonged periods. Monitor height of childn receiving prolonged treatment. Possibility of impaired adrenal response in patients transferring from oral steroid therapy. History of DM. Concomitant use w/ ritonavir, ketoconazole & other strong CYP3A4 inhibitors. Discontinue use if paradoxical bronchospasm occurs. Pregnancy & lactation. Childn <4 yr.
Side Effects / Adverse Reactions:
Headache. Mouth & throat candidiasis, pneumonia (in COPD patients); hoarseness/dysphonia; muscle cramps, arthralgia.
Dosage / Direction for Use:
Diskus ROAD Adult & adolescent ≥12 yr 1 inhalation of Seretide 100 or 250 or 500 bid. Childn ≥4 yr 1 inhalation of Seretide 100 bid. COPD Adult 1 inhalation of Seretide 250-500 bid. MDI ROAD Adult & adolescent ≥12 yr 2 inhalations of Seretide 25/50 or 25/125 or 25/250 bid. Childn ≥4 yr 2 inhalations of Seretide 25/50 bid. COPD Adult 2 inhalations of Seretide 25/125 or 25/250 bid.