POLYNERV TABLET 1000MCG (TABLET)

Dosage / Direction for Use Prophylaxis 1-2 tab daily. Therapeutic 2-4 tab daily. Administration May be taken with or without food: May be taken w/ meals to reduce GI discomfort. Special Precautions Cyanocobalamin (Vitamin B12) should not be used to treat megaloblastic anemia of pregnancy. Administration of doses greater than 10 mcg of Vitamin B12 daily may produce a haematological response in patients with folate deficiency; indiscriminate use may mask the precise diagnosis. Cyanocobalamin or hydroxocobalamin should, if possible, not be given to patients with suspected vitamin B12 deficiency without first confirming the diagnosis. Regular monitoring of the blood is advisable. Contraindications Contraindicated in patients with history of hypersensitivity to the components. Cyanocobalamin should not be given to patients with suspected vitamin B12 deficiency without confirmation of the diagnosis. Drug Interactions Drugs that increase the requirements for pyridoxine include hydralazine, isoniazid, penicillamine and oral contraceptives, neomycin, aminosalicytic acid, histamine H2-antagonists and colchicine may reduce the absorption of vitamin B12 from the gastrointestinal tract. Oral contraceptives may reduce serum concentrations of vitamin B12. Though unlikely to be of clinical significance, many interactions of vitamin B12 should be taken into account when performing assays for blood concentration.