PLETAAL TABLET 50MG (TABLET)

Dosage / Direction for Use Adult Pletaal 100 mg bid. Pletaal SR 200 mg once daily. Administration Should be taken on an empty stomach: Take at least 30 min before or 2 hr after meals. Contraindications Cerebral infarction; CHF. Hemophilia, increased capillary fragility, hemoptysis; intracranial, digestive & urinary tract & vitreous body hemorrhage. Women of childbearing potential. Pregnancy. Special Precautions Monitor for any anginal symptoms eg, chest pain. Asymptomatic cerebral infarction. Concomitant use w/ anticoagulants, antiplatelet & thrombolytic drugs or prostaglandin E1 or its derivatives. Risk of hemorrhagia during menstruation; bleeding tendency or predisposition; severe hepatic or renal impairment; coronary artery stenosis; DM or abnormal glucose tolerance; malignant HTN. Discontinue use or reduce dose if excessive increase in pulse rate is observed in patients w/ coronary artery stenosis. Long-term use in patients w/o CHF. Lactation. Childn. Elderly. Side Effects / Adverse Reactions Rash; palpitation, tachycardia, hot flushes; headache/dull headache, dizziness, insomnia, numbness; abdominal pain, nausea, vomiting, anorexia, diarrhea, heartburn & abdominal distention; SC hemorrhage; increased ALT, AST, alkaline phosphatase & lactate dehydrogenase; sweating, edema & chest pain. Interactions Anticoagulants eg, warfarin, antiplatelets eg, aspirin & ticlopidine HCl, thrombolytics eg, urokinase & alteplase, prostaglandin E1 or its derivatives eg, alprostadil & limaprost alfadex; CYP3A4 inhibitors including macrolides eg, erythromycin, HIV PIs eg, ritonavir, azole antimycotics eg, itraconazole & miconazole, cimetidine, diltiazem HCl & grapefruit juice; CYP2C19 inhibitors eg, omeprazole