Dosage / Direction for Use
Prophylaxis of thromboembolic events 75 mg once daily. Management of acute coronary syndromes including unstable angina & non-Q wave MI Single 300 mg loading dose followed by 75 mg daily.
Administration
May be taken with or without food.
Side Effects / Adverse Reactions
Dyscrasias. Serum sickness, interstitial pneumonitis, erythema multiforme, Stevens-Johnson syndrome, lichen planus, myalgia (rarely). Should be stopped 5-7 days before elective surgery.
Interactions
Increase risk of bleeding w/ anticoagulants, antiplatelets & NSAIDs. Reduce the conversion of bupropion to its active metabolite. Myopathy & rhabdomyolysis in patients receiving ciclosporin w/ statins (atorvastatin, lovastatin or simvastatin).