NEXIUM 20MG TABLET (TABLET)
Contents
Esomeprazole
Indications / Uses
Erosive reflux esophagitis; long-term management of patients w/ healed esophagitis to prevent relapse; symptomatic treatment of GERD. Upper GI symptoms or healing of gastric ulcers associated w/ NSAIDs therapy. Prevention of gastric &/or duodenal ulcers associated w/ NSAIDS or low dose aspirin therapy. Maintenance of hemostasis & prevention of rebleeding of gastric or duodenal ulcers. Tab: In combination w/ an appropriate antibacterial therapeutic regimen for the eradication of H. pylori & healing of H. pylori associated duodenal ulcer & prevention of relapse of peptic ulcer in patients w/ H. pylori-associated ulcers. Pathological hypersecretory conditions including Zollinger-Ellison syndrome & idiopathic hypersecretion. Granules: GERD in childn 1-11 yr. Patients having difficulty swallowing dispersed tab. Inj: Alternative to oral therapy when oral route is not appropriate for GERD in patients w/ erosive reflux esophagitis &/or severe symptoms of reflux.
₱129.75
Availability:
In stock
SKU
8890
Administration
May be taken with or without food:Tab: Swallow whole w/ liqd. Do not chew/crush. May also be dispersed in ½ glass of non-carbonated water. No other liqd should be used. Stir until the tab disintegrate & drink the liqd w/ the pellets immediately or w/in 30 min. Rinse the glass w/ ½ glass of water & drink. Do not chew/crush the pellets. For patients who cannot swallow, the tab contents can be dispersed in non-carbonated water & administered through a gastric tube. Granules: Empty contents of a 10 mg sachet into a container w/ 1 tbsp of non-carbonated water and stir. Leave for a few minutes to thicken. Stir again and take within 30 min. Rinse remaining contents w/ water and drink immediately. For patients who cannot swallow, the mixt can be administered through a nasogastric tube w/ a syringe. Refill syringe w/ water, shake and flush any remaining contents from the nasogastric tube.
Contraindications
Hypersensitivity to esomeprazole & substituted benzimidazoles.
Special Precautions
Exclude malignancy in the presence of significant unintentional wt loss, recurrent vomiting, dysphagia, hematemesis or melena; & when gastric ulcer is suspected or present. Patients on long-term & on-demand treatment. Concurrent therapy of CYP3A4-metabolized drugs eg, cisapride. Concomitant use w/ atazanavir & nelfinavir is not recommended; clopidogrel. Monitor patients at risk for developing osteoporosis or osteoporotic fractures. Severe renal or hepatic impairment. Pregnancy. Do not use during lactation. Granules: Rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency.
Side Effects / Adverse Reactions
Headache; abdominal pain, diarrhea, flatulence, nausea, vomiting, constipation. Inj: Administration site reactions
Interactions
May decrease (eg, ketoconazole, itraconazole & erlotinib) or increase (eg, digoxin) absorption of drugs. Decreased clearance of diazepam. Increased trough plasma levels of phenytoin in epileptic patients. Elevated INR w/ warfarin or other coumarine derivatives. Decreased max inhibition of platelet aggregation of clopidogrel. Increased Cmax & AUC of cilostazol. Increased AUC & prolonged elimination t½ of cisapride. Increased serum levels of tacrolimus & other antiretroviral drugs eg, saquinavir. Increased methotrexate levels. Decreased serum levels of antiretroviral drugs eg, atazanavir & nelfinavir. May double the exposure w/ clarithromycin & voriconazole. Decreased serum levels w/ CYP2C19 or CYP3A4 inducers (eg, rifampicin & St. John's wort).
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