MEDROL TAB 16MG (TABLET)

Special Precautions: May increase susceptibility to infection & mask some signs of infection & new infections may appear during use; Kaposi's sarcoma. Angioedema. Hypothalamic-pituitary-adrenal (HPA) suppression; can produce or aggravate Cushing's syndrome; enhanced effect on patients w/ hypothyroidism. Can increase blood glucose, worsen preexisting diabetes & predispose those on long-term therapy to DM. Psychic derangements; aggravated emotional instability or psychotic tendencies. Patients w/ seizure disorders; myasthenia gravis; epidural lipomatosis. Possible corneal perforation; may produce posterior subcapsular & nuclear (in childn) cataracts, exophthalmos or increased IOP; secondary fungal & viral infections of the eye; retinal detachment. Additional CV effects in patients w/ existing CV risk; CHF. Venous thromboembolism; HTN. May produce acute pancreatitis, may mask symptoms of peptic ulcer, peritonitis or other signs or symptoms associated w/ GI disorders eg, perforation, obstruction or pancreatitis; increased risk of developing GI ulcers; non-specific ulcerative colitis. Hepatobiliary disorders. Acute myopathy; osteoporosis. Scleroderma renal crisis; renal insufficiency. Elevation of BP, salt & water retention & increased K excretion. Not for the treatment of traumatic brain injury. Pheochromocytoma crisis. Growth suppression, risk from raised intracranial pressure & may produce pancreatitis in childn. Side Effects / Adverse Reactions: Infections & opportunistic infections, peritonitis; leukocytosis; hypersensitivity, anaphylactic/anaphylactoid reactions; Cushingoid, hypopituitarism, steroid w/drawal syndrome; metabolic acidosis, Na/fluid retention, hypokalemic alkalosis, dyslipidemia, impaired glucose tolerance, increased insulin requirement, lipomatosis, increased appetite; affective/psychotic disorder, psychotic behavior, mental disorder, personality change, confusional state, increased intracranial pressure, seizure, amnesia, cognitive disorder, dizziness, headache; chorioretinopathy, cataract, glaucoma, exophthalmos; vertigo; CHF; thrombosis, HTN, hypotension; pulmonary embolism, hiccups; peptic ulcer, intestinal perforation, gastric hemorrhage, pancreatitis, ulcerative esophagitis, esophagitis, abdominal distention/pain, diarrhea, dyspepsia, nausea; angioedema, hirsutism, petechiae, ecchymosis, skin atrophy, erythema, hyperhidrosis, skin striae, rash, pruritus, urticaria, acne; muscular weakness, myalgia, myopathy, muscle atrophy, osteoporosis, osteoneurosis, pathological fracture, neuropathic atropathy, arthralgia, growth retardation; irregular menstruation; impaired healing, peripheral edema, fatigue, malaise; increased IOP, decreased carbohydrate tolerance, decreased blood K, increased urine Ca, increased ALT/AST, increased blood alkaline phosphatase, increased BUN, suppression of reactions to skin test. Dosage / Direction for Use: Individualized dosage. Multiple sclerosis 200 mg/day. Cerebral edema 200-1,000 mg/day. Organ transplantation Up to 7 mg/kg/day.