LYRICA 75MG TAB (TABLET)

Special Precautions: Discontinue immediately if symptoms of angioedema eg, facial, perioral or upper airway swelling occur. Do not take in patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Diabetic patients. Transient visual blurring & other changes in visual acuity; loss of consciousness, confusion, mental impairment; CHF. Evaluate patients w/ history of drug abuse. May cause dizziness & somnolence influencing the ability to drive or operate machinery. Pregnancy & lactation. Not recommended in childn <12 yr & adolescents. Elderly >65 yr. Side Effects / Adverse Reactions: Dizziness, somnolence. Nasopharyngitis; increased appetite; euphoric mood, confusion, irritability, depression, disorientation, insomnia, decreased libido; ataxia, abnormal coordination, tremor, dysarthria, amnesia, memory impairment, disturbance in attention, paresthesia, hypoesthesia, sedation, balance disorder, lethargy; blurred vision, diplopia; vertigo; vomiting, constipation, flatulence, abdominal distension, dry mouth; muscle cramp, arthralgia, back pain, pain in limb, cervical spasm; peripheral edema, edema, abnormal gait, fall, feeling drunk, feeling abnormal, fatigue; increased wt. Dosage / Direction for Use: 150-600 mg/day in 2 or 3 divided doses. Neuropathic pain Initially 150 mg/day, may be increased to 300 mg/day after an interval of 3-7 days. Max: 600 mg/day after an additional 7-day interval. Fibromyalgia 300-450 mg/day in 2 divided doses. Begin at 75 mg bid & may be increased to 150 mg bid w/in 1 wk based on efficacy & tolerability. May be further increased to 225 mg bid. Max: 600 mg/day after an additional wk. Epilepsy Initially 150 mg/day, may be increased to 300 mg/day after 1 wk. Max: 600 mg/day after an additional wk. GAD Initially 150 mg/day; dose range: 150-600 mg/day as 2 or 3 divided doses. May be increased to 300 mg/day after 1 wk, following an additional wk, may be increased to 450 mg/day. Max: 600 mg/day after an additional wk. Discontinuation: Gradually w/draw over a min of 1 wk. Renal impairment CrCl ≥60 mL/min Starting dose: 150 mg/day bid or tid, max: 600 mg/day bid or tid, ≥30 to <60 mL/min Starting dose: 75 mg/day bid or tid, max: 300 mg/day bid or tid, ≥15 to <30 mL/min Starting dose: 25-50 mg/day once daily or bid, max: 150 mg/day once daily or bid, <15 mL/min Starting dose: 25 mg once daily, max: 75 mg once daily. Supplementary dose following hemodialysis 25 mg as a single dose. Max: 100 mg as a single dose.