Dosage / Direction for Use: Tablet may be chewed then swallowed without water or swallowed whole with water.
Recommended Adult Dose: 1 to 2 tablets to be taken one hour after each meal and at bedtime.
Or, as prescribed by a doctor.
If taken more than the recommended dosage, consult a doctor.
Missed Dose: If the patient misses a dose, just give the next dose and the subsequent doses at the recommended time or schedule.
Do not double the dose unless recommended by a doctor.
Overdosage: Signs and Symptoms of Overdosage: Aluminum Hydroxide may accumulate in bones, lungs and nerve tissues in patients with kidney failure. Large doses or chronic use of Aluminum may also cause phosphorus depletion which is characterized by anorexia, malaise, and muscle weakness. Prolonged use may cause kidney stones, osteomalacia (softening of the bones) and osteoporosis.
Hypotension, nausea, vomiting, ECG change, respiratory or mental depression, and coma have also been reported with large doses of Magnesium in patients with severe kidney disease.
Simeticone overdosage is not expected to cause any clinically important effects.
If the patient has taken more than the recommended dosage, consult a doctor.
Administration:Should be taken on an empty stomach: Take 1 hr after each meal & at bedtime. Swallow whole w/ water. May be chewed then swallow w/o water.
Contraindications: Hypersensitivity. Kidney disease, intestinal obstruction, appendicitis, fecal impaction, gastric outlet obstruction, constipation, phosphate depletion, & low serum phosphate, osteomalacia.
Special Precautions
Risk of Al & Mg accumulation & toxicity w/ advanced kidney disease. Phenylketonurics. Concomittant use w/ other medicines. Consult if to use for >14 days.
Use In Pregnancy & Lactation: Ask a doctor before use if the patient is pregnant or breastfeeding.
Side Effects / Adverse Reactions: Diarrhea or constipation.
Interactions: May decrease absorption of tetracycline & Fe; take tetracycline 1 hr before or 2 hr after antacids & 2 hr before or 3 hr after Fe-containing prep. May decrease absorption of oral digoxin or indomethacin, INH, quinolones (eg, ciprofloxacin, ofloxacin), ketoconazole. May increase urinary excretion due to changes in urine pH & decrease blood conc of salicylates eg, aspirin. Increase in urine pH may decrease excretion of weakly basic drugs (eg, quinidine, chlorpromazine, propranolol, diazepam) & increase excretion of weakly acidic drugs (eg, phenytoin, pentobarbital, warfarin). May increase absorption of dicumarol, diazepam & pseudoephedrine. May decrease the rate of chlordiazepoxide absorption. May reduce the bioavailability of biphosphonates (eg, alendronate, etidronate, risedronate).
Mechanism of Action: This product contains a combination of antacids, Aluminum Hydroxide and Magnesium Hydroxide, which effectively increase gastric pH by neutralizing the acid produced in the stomach.
This product also contains Simeticone, a water-repellant with low surface tension used to relieve bloating and gassiness by causing small bubbles to coalesce to large bubbles, which are passed more easily.