ISOXILAN TABLET 10MG (TABLET)

Dosage / Direction for Use Uterine hypermotility Oral 20 mg tid-qid when uterine contractions have ceased for at least 12 hr w/ parenteral isoxsuprine. IV Infusion Initially, 100 mg in 500 mL infusion fluid w/ starting infusion rate of 0.5 mL/min (10 drops/min). Increase infusion rate in increments of 10 drops/min at 10 min interval. IM inj 10 mg every 3 hr for 24 hr then 4-6 hr for 48 hr. Circulatory disturbances Oral 20 mg tid-qid. Inj 5-10 mg IM tid. Administration May be taken with or without food: May be taken w/ meals, milk or antacids to minimise GI discomfort. Contraindications Following recent arterial hemorrhage, known heart disease & severe anemia. Hypotension, tachycardia, premature detachment of the placenta, immediately postpartum & premature labor if there is infection. Special Precautions Discontinue if rash develops. To avoid pulmonary edema in women treated for premature labor, monitor for state of hydration, cardiac & resp function. Keep fluid infusions vol to the min. For infusion, hypotonic dextrose is preferred over isotonic saline soln. If signs of pulmonary edema develop, discontinue immediately & institute diuretic therapy. Childn. Side Effects / Adverse Reactions Trembling, nervousness, weakness, dizziness, flushing, transient palpitation, tachycardia, chest pain, hypotension, abdominal distress, nausea, vomiting, intestinal distention, & severe rash. Interactions May cause severe hypotension w/ other vasodilators & antihypertensives.