ISORDIL SUBLINGUAL TABLET 5MG (TABLET)

Dosage / Direction for Use Angina pectoris Tab 5-30 mg qid. SL tab 5-10 mg every 2-3 hr as prophylaxis. May be supplemented by 5-10 mg prior to stressful situations likely to provoke an attack. Acute CHF Tab 10-40 mg qid or as needed. SL tab 5-10 mg every 2 hr or as needed. Chronic CHF Initially 5-10 mg by SL every 2 hr or as needed. Maintenance: 20-40 mg qid orally or as needed. Administration Should be taken on an empty stomach: Take 30 min before meals. Contraindications Hypersensitivity or idiosyncrasy. Concomitant use w/ soluble guanylate cyclase (GC) stimulator eg, riociguat. Special Precautions Paradoxical side effects in sensitive patients. Hemodynamic monitoring & frequent clinical assessment w/ the use of organic nitrates in early infarction. Severe hypotensive response. Paradoxical bradycardia & increased angina pectoris may accompany nitrate-induced hypotension. Blood vol depletion from diuretic therapy; low systolic BP (eg, <90 mmHg). Monitor pulmonary capillary pressure not to fall below 15 mmHg or systolic BP below physiological range. In combination w/ Ca channel blockers. May aggravate angina caused by hypertrophic cardiomyopathy. Tolerance & cross-tolerance to other nitrates & nitrites may occur. Avoid abrupt w/drawal. Pregnancy & lactation. Childn. Elderly. Side Effects / Adverse Reactions Vascular headache. Cutaneous vasodilation w/ flushing; transient episodes of dizziness & weakness, other signs of cerebral ischemia associated w/ postural hypotension; drug rash &/or exfoliative dermatitis. Interactions May enhance effect w/ alcohol. Possible additive hypotensive effects w/ antihypertensive drugs, β adrenergic blockers, or phenothiazines. May amplify the vasodilatory effect w/ sildenafil. Potentiate hypotensive effects w/ riociguat.