ISOPTIN 80MG TABLET (TABLET)
Contents
Verapamil HCl
Indications / Uses
Tab: Treatment of CAD including chronic stable angina pectoris; unstable angina pectoris; vasospastic angina pectoris (Prinzmetal's angina, variant angina); post MI angina in patients w/o heart failure if β-blockers are not indicated; disturbance of cardiac rhythm in paroxysmal supraventricular tachycardia, atrial fibrillation/flutter w/ rapid AV conduction [except in Wolff-Parkinson-White (W-P-W) or Lown-Ganong-Levine (L-G-L) syndromes]; high BP (HTN). Inj: Treatment of supraventricular tachyarrhythmias, which includes rapid conversion to sinus rhythm of paroxysmal supraventricular tachycardias including those associated w/ accessory bypass tracts (W-P-W or L-G-L syndromes); temporary control of rapid ventricular rate in atrial flutter or fibrillation except when the atrial flutter &/or fibrillation are associated w/ accessory bypass tracts (W-P-W or L-G-L syndromes).
₱56.65
Availability:
In stock
SKU
6351
Dosage / Direction for Use
Tab Adult CAD, paroxysmal supraventricular tachycardia, atrial flutter/fibrillation IR: 120-480 mg in 3 or 4 divided doses; SR: 120-480 mg in 1 or 2 divided doses. HTN IR: 120-480 mg in 3 divided doses; SR: 120-480 mg in 1 or 2 divided doses. Childn 6-14 yr 80-360 mg in 2-4 divided doses, up to 6 yr 80-120 mg in 2-3 divided doses. Inj Adult Initially 5-10 mg (0.075-0.15 mg/kg) IV bolus over at least 2 min. Repeat dose: 10 mg (0.15 mg/kg) 30 min after the 1st dose. Childn 1-15 yr 0.1-0.3 mg/kg (single-dose range: 2-5 mg) IV bolus over at least 2 min (max: 5 mg), 0-1 yr 0.1-0.2 mg/kg (single dose range: 0.75-2 mg) IV bolus over at least 2 min under continuous ECG monitoring. Repeat dose: Childn 1-15 yr 0.1-0.3 mg/kg (single dose range: 2-5 mg) 30 min after the 1st dose. Max single dose: 10 mg, 0-1 yr 0.1-0.2 mg/kg (single dose range: 0.75-2 mg) 30 min after the 1st dose
Administration
Should be taken with food: Take w/ or shortly after meals. Swallow whole, do not suck/chew.
Contraindications
Hypersensitivity. Cardiogenic shock; 2nd- & 3rd-degree AV block & sick sinus syndrome (except in patients w/ a functioning artificial pacemaker); heart failure w/ reduced ejection fraction of <35% &/or pulmonary wedge pressure >20 mmHg; atrial fibrillation/flutter in the presence of an accessory bypass tract (W-P-W or L-G-L syndromes). Combination w/ Ivabradine. Inj: Severe hypotension. Patients receiving IV β-blockers (eg, propranolol); ventricular tachycardia.
Administration
Should be taken with food: Take w/ or shortly after meals. Swallow whole, do not suck/chew.
Contraindications
Hypersensitivity. Cardiogenic shock; 2nd- & 3rd-degree AV block & sick sinus syndrome (except in patients w/ a functioning artificial pacemaker); heart failure w/ reduced ejection fraction of <35% &/or pulmonary wedge pressure >20 mmHg; atrial fibrillation/flutter in the presence of an accessory bypass tract (W-P-W or L-G-L syndromes). Combination w/ Ivabradine. Inj: Severe hypotension. Patients receiving IV β-blockers (eg, propranolol); ventricular tachycardia.
Side Effects / Adverse Reactions
Dizziness, headache; bradycardia; flushing, hypotension; constipation, nausea; peripheral edema.
Interactions
Additive hypotensive effect w/ prazosin, terazosin. Decreased clearance of oral quinidine, theophylline, digitoxin. Increased AUC of carbamazepine, imipramine, cimetidine, everolimus, sirolimus, simvastatin, doxorubicin. Decreased plasma conc w/ phenytoin. Increased Cmax & AUC of glyburide, colchicine, buspirone, midazolam, metoprolol, propranolol, digoxin, cyclosporine, almotriptan, dabigatran, grapefruit juice. Possible increased levels w/ clarithromycin, erythromycin, telithromycin, tacrolimus, atorvastatin, lovastatin. Decreased AUC, Cmax & oral bioavailability of rifampicin. Increased clearance w/ phenobarb, sulfinpyrazone. Decreased AUC w/ St. John's wort. Increased plasma conc w/ HIV antivirals eg, ritonavir, ethanol. Increased neurotoxicity w/ lithium. May potentiate neuromuscular-blocking effects of neuromuscular blockers. Increased risk of bleeding w/ acetylsalicylic acid. Potentiation of hypotensive effects of antihypertensives, diuretics, vasodilators. Inj: Risk of CV depression w/ inhalation anesth. Protein bound drugs.
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