ILOSONE DROPS 10ML (BOTTLE)

Dosage / Direction for Use Adult 250 mg 6 hrly, may be increased up to ≥4 g/day. Childn 30-50 mg/kg/day in divided doses. Severe infections: Dosage may be doubled. Pharyngitis & tonsillitis Usual dose 20-50 mg/kg/day in divided doses. ≥36 kg 1,000 mg, 25-36 kg 750 mg, 18-25 kg 500 mg, 11-18 kg 375 mg, <10 kg 250 mg. Prophylaxis of streptococcal infections in persons w/ history of rheumatic heart disease 250 mg bid. Prophylaxis against bacterial endocarditis in penicillin allergic patient w/ congenital heart disease/rheumatic/other acquired valvular heart disease when undergoing dental procedure/ surgery of the upper resp tract Adult 1 g orally 1 hr pre-op, 500 mg orally 6 hr post-op. Childn 20 mg/kg orally 1 hr pre-op, 10 mg/kg orally 6 hr post-op. Primary syphilis 20 g in divided doses for 10 days. Dysenteric amoebiasis Adult 250 mg qid for 10-14 days. Childn 30-50 mg/kg/day in divided doses for 10-14 days. Pertussis 40-50 mg/kg/day in divided doses for 5-14 days. Legionnaire's disease 1-4 g daily in divided doses. Conjunctivitis in newborn Oral susp 50 mg/kg/day in 4 divided doses for 2 wk. Pneumonia of infant Oral susp 50 mg/kg/day in 4 divided doses for 3 wk. Urogenital infections during pregnancy 500 mg qid for 7 days. For women who cannot tolerate this regimen, reduce dose to 250 mg qid for 14 days. Uncomplicated urethral, endocervical/rectal infections 500 mg qid for 7 days Administration Should be taken on an empty stomach: Best taken 1 hr before or 2 hr after meals. May be taken w/ meals to reduce GI discomfort. Contraindications Patients with known hypersensitivity to erythromycin. Patients taking terfenadine, astemizole, cisapride, pimozide, verapamil or diltiazem (see Interactions). Patients with known history of sensitivity to erythromycin estolate and for those with preexisting liver disease. Interactions Theophylline, digoxin, anticoagulant, ergotamine or dihydroergotamine, triazolam, midazolam, carbamazepine, cyclosporin, hexobarbital, phenytoin, alfentanil, disopyramide, quinidine, lincomycin, clindamycin & probenecid. HMG-CoA reductase inhibitors eg lovastatin & simvastatin, bromocriptine. PDE5 inhibitors eg sildenafil, tadalafil & vardenafil. Terfenadine. Cisapride, astemizole, pimozide, verapamil or diltiazem Side Effects / Adverse Reactions GI disturbances eg abdominal cramping & discomfort, nausea, vomiting, diarrhea. Urticaria, other skin rashes, anaphylaxis. Hearing loss &/or tinnitus. Infantile hypertrophic pyloric stenosis Special Precautions Impaired hepatic function. May interfere w/ AST (SGOT) & urinary catecholamine determination. Monitor creatinine kinase & serum transaminase levels. Pseudomembranous colitis. Pregnancy & lactation. Infants.