Dosage
The dosage should be determined according to the individual requirements of the patient.
New Patients: New patients can be started on Humulin in the same manner as they would be on animal-source insulin. Patients should be monitored closely during the adjustment period.
Transfer Patients: When transferring patients, most patients should be initiated at the same dose and dosage schedule. However, when a patient on high doses of animal insulin is initiated to Humulin N or Humulin R, it is appropriate to reduce the starting dosage and monitor the patient carefully.
Administration: Vial: Given by SC or IM injection. Cartridge: Given by SC injection only. It should not be used IV or IM
Contraindications
Protamine zinc and isophane insulin, and insulin zinc suspensions should never be given IV and are not indicated for hyperglycemic coma.
Hypoglycemia.
Interactions
OCs, corticosteroids, thyroid replacement therapy; oral hypoglycemics, salicylates (eg, acetylsalicylic acid), sulfa antibiotics, certain antidepressants (MAOIs), thiazolidinediones, β-blockers & alcohol.