BUSCOPAN PLUS 4S PROMO (TABLET)

Dosage / Direction for Use: Adult 1-2 tab tid. Max: 6 tab daily. Administration: May be taken with or without food: Swallow whole w/ sufficient amount of water, do not chew. Contraindications: Hypersensitivity. Myasthenia gravis, mechanical stenosis in the GIT, paralytical or obstructive ileus, megacolon, severe hepatocellular insufficiency (Child-Pugh C); rare hereditary conditions. Special Precautions: Seek medical advice in case of persisting severe, unexplained abdominal pain w/ symptoms eg, fever, nausea, vomiting, changes in bowel movement, abdominal tenderness, decreased BP, fainting or blood in stool. G6PD deficiency, hepatic or renal dysfunction, Gilbert's syndrome, hepatocellular insufficiency (Child-Pugh A/B). Monitor blood count, renal & liver function after prolonged use. Discontinue use at 1st signs of hypersensitivity reaction. Avoid abrupt discontinuation after prolonged use at high doses. Not to be taken for >3 days. Patients prone to narrow-angle glaucoma, susceptible to intestinal or urinary outlet obstructions & inclined to tachyarrhythmia. Patients on controlled Na diet. Not recommended during pregnancy. Lactation. Childn <10 yr. Paracetamol: Other drugs containing paracetamol. May induce headaches w/ extensive use of high doses of analgesics. Side Effects / Adverse Reactions: Pancytopenia, agranulocytosis, thrombocytopenia, leukopenia; skin reactions, abnormal sweating, pruritus, urticaria, nausea, erythema, decreased BP including shock, anaphylactic shock, anaphylactic reactions, drug eruption, dyspnoea, hypersensitivity, angioedema, rash, exanthema; tachycardia; bronchospasm; dry mouth; increased transaminases; urinary retention. Interactions: Hypnotics & antiepileptics (eg, glutethimide, phenobarb, phenytoin, carbamazepine); rifampicin; potentially hepatotoxic substances & alcohol. Intensified anticholinergic effects of tri- & tetracyclic antidepressants, antihistamines, antipsychotics, quinidine, amantadine, disopyramide & other anticholinergics (eg, tiotropium, ipratropium, atropine-like compd). Diminution of effects of both drugs on GIT w/ dopamine agonists eg, metoclopramide. Enhanced tachycardic effects of β-adrenergic agents. Paracetamol: Long-term use w/ oral anticoagulants. Enhanced tendency of neutropenia w/ zidovudine. Concomitant use w/ probenecid. Reduced absorption w/ cholestyramine.