Dosage / Direction for Use
Tab Adult & childn ≥12 yr 1 tab every 6 hr. Syr Adult 3 tsp, 7-12 yr 2 tsp, 2-6 yr 1 tsp, <2 yr As prescribed. To be given 6 hrly.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. High BP or severe heart disease; anemia, kidney or liver disease. Pregnancy & lactation.
Special Precautions
Patients w/ high BP, toxic goiter, benign prostatic hypertrophy, heart rate irregularity, glaucoma, diabetes & those taking antidepressants. Patients taking more than max daily amount (4 g in 24 hr), taking other medicines containing paracetamol, adult w/ ≥3 alcoholic drinks everyday. Kidney or liver disease. Concomitant use w/ warfarin. Observe caution while driving or performing other tasks requiring alertness. Discontinue if fever gets worse or lasts >3 days.
Side Effects / Adverse Reactions
Phenylpropanolamine HCl Aggressiveness (particularly in young childn), anxiety, confusion, insomnia/sleep disturbance, nervousness; agitation, dizziness, restlessness; sudden persistent severe headache, tremor; blurred vision; chest tightness, palpitation; high BP; nausea; irritability. Chlorpheniramine maleate Insomnia/sleeplessness, nervousness; headache, tremor; blurred vision; visual disturbance; tinnitus; chest tightness; increased or decreased BP; constipation, diarrhea, GI discomfort, nausea, vomiting; muscle weakness; difficulty urinating; mouth, nose & throat dryness; irritability. Paracetamol Agranulocytosis, leukopenia, neutropenia, pancytopenia, thrombocytopenia; allergic reactions; minor stomach & intestinal disturbances; Stevens-Johnson syndrome, toxic epidermal necrolysis & acute generalized exanthematous pustulosis.
Interactions
Increased toxicity w/ sympathomimetic agents (eg, epinephrine) & general anesth (eg, halothane). Hypertensive crisis w/ medicines for depression eg, MAOIs (eg, selegiline, moclobemide) & TCAs (eg, amitriptyline, imipramine). May potentiate drowsiness w/ anxiolytics (eg, alprazolam, diazepam) & hypnotics (eg, zolpidem). Phenylpropanolamine HCl Additive increase in BP w/ caffeine. Paracetamol Increased anticoagulation effect of warfarin. Increase susceptibility to the harmful effects to the liver w/ anticonvulsants (eg, phenobarb, phenytoin). May accelerate absorption w/ metoclopramide or domperidone. May reduce absorption w/ cholestyramine.