Dosage / Direction for Use: Wash hands before and after each application unless mupirocin ointment is used to treat a hand condition.
Clean the affected and adjacent area with mild soap and water.
Rinse thoroughly and pat dry.
Apply a small amount of mupirocin ointment on the affected area three times daily for up to 10 days, or as prescribed by a physician. The treated area may be covered with gauze dressing if needed.
Re-assess patients not showing a clinical response within 3 to 5 days.
Do not apply concurrently with other topical medications [see Interactions].
Overdosage: The toxicity of mupirocin is very low. In case of overdosage, symptomatic treatment is recommended. In case of accidental swallowing, seek medical help immediately.
Contraindications: Hypersensitivity. Not for ophth or intranasal use. Do not use at the site of central venous cannulation; conditions where large amount of polyethylene glycol may be absorbed eg, open wounds, extensive burns, broken skin especially in patients w/ moderate or severe renal impairment.
Special Precautions: Avoid contact w/ eyes; prolonged use. Discontinue treatment if sensitivity or severe local irritation occurs.
Use In Pregnancy & Lactation: Pregnancy: (Pregnancy Category B). Animal studies have demonstrated no evidence of impaired fertility or harmful effects to the fetus. There are no adequate and well-controlled clinical studies in pregnant women. Since animal studies are not always predictive of human response, use this drug during pregnancy only if clearly needed.
Lactation: It is not known whether mupirocin is excreted in human milk. Since many drugs are distributed into human milk, use with caution when breastfeeding. If a cracked nipple is to be treated with mupirocin, lactation from the affected breast should be maintained by manual expression until the end of treatment. During this time, milk from the affected breast should be discarded.
Side Effects / Adverse Reactions: Rarely, application site reactions, burning, stinging, pain, pruritus, rash, dryness, erythema, tenderness, cellulitis, pain or bleeding secondary to eczema, secondary wound infection, urticaria, swelling, contact dermatitis, furunculosis, exfoliative dermatitis, increased exudates, cutaneous sensitization reactions.
Interactions: Salicylic acid 2%; water-containing vehicles eg, coal tar soln.