DIATABS CAP 2MG (CAPSULE)

Dosage / Direction for Use: Adult Acute diarrhea 2 cap followed by 1 cap after each loose bowel movement. Max: 16 mg/day (8 cap). Discontinue if there is no improvement after 2 days. Chronic diarrhea 2 cap followed by 1 cap after each loose bowel movement. Maintenance dose: 2-4 cap/day. Overdosage: Signs and Symptoms of Overdosage: Loperamide overdose may result in constipation, central nervous system (CNS) depression (e.g., drowsiness and dizziness), paralytic ileus (temporary absence of intestinal movement), and urinary retention (decreased urination). In adults, reported overdosage within 24 hours resulted in nausea after 40 mg (20 capsules) and vomiting after 60 mg (30 capsules). If the patient has taken more than the recommended dosage (i.e., more than 8 capsules per day), consult a doctor or a Poison Control Center right away. Administration: May be taken with or without food. Contraindications: If the patient is allergic to loperamide or any ingredient in the product. If it is for a child under 12 years old. If the patient is pregnant or breastfeeding. If the patient is constipated and also in whom constipation should be avoided (e.g., diarrhea resulting from infections). If the abdomen is swollen or the patient has abdominal pain. If the patient has acute dysentery which is characterized by blood in stools and high fever. If the patient has pseudomembranous colitis (diarrhea associated with antibiotics), active ulcerative colitis, meningitis, or a history of liver disease. Special Precautions:Do not take more than the recommended dose. Stop use and consult the doctor if: Any undesirable effect occurs or acute diarrhea persists for more than two days, if symptoms worsen, if abdominal swelling or bulging develops, or if fever develops. The patient has Acquired Immune Deficiency Syndrome (AIDS) and any signs of abdominal swelling or bulging. There have been isolated reports of toxic megacolon (rapid widening of the colon accompanied by infection or inflammation) in AIDS patients treated with loperamide. A serious condition may develop if too much fluid has been lost by the body due to diarrhea. Consult a doctor if any of the following conditions develop: Decreased urination, Dizziness and lightheadedness, Dryness of mouth, Increased thirst, Wrinkled skin. Use In Pregnancy & Lactation: This medication is contraindicated if the patient is pregnant or breastfeeding. Side Effects / Adverse Reactions: Dry mouth, abdominal pain, distention or discomfort, nausea, vomiting, fatigue, flatulence, dyspepsia, constipation, epigastric pain, paralytic ileus, toxic megacolon. Rarely, drowsiness & dizziness; pruritus, rash, urticaria, angioedema & bullous eruption including Stevens-Johnson syndrome, erythema multiforme, & toxic epidermal necrolysis. Very rarely, allergic reactions including unexplained wheezing, shortness of breath, passing out or face & throat swelling. Interactions: Concomitant administration with the following may result in increased loperamide plasma levels: Ritonavir (used to treat Human Immunodeficiency Virus), Quinidine (used to treat abnormal heart rhythms), Oral desmopressin (used to treat excessive urination), Itraconazole or ketoconazole (used to treat fungal infections), Gemfibrozil (used to lower cholesterol). Medicine that slow down the action of the stomach and intestines (e.g., some medicines for depression and cold and allergy medications) as these may increase the constipating effect of loperamide. Medicines that cause drowsiness since loperamide may also cause drowsiness. Mechanism of Action: This medicine contains loperamide, an antidiarrheal agent which slows intestinal movement and reduced fluid and salt loss in the intestines, resulting in improved stool consistency.