DAKTARIN CREAM 5G (PIECE)

Dosage / Direction for Use: Apply bid for 2-6 wk. Continue treatment at least 1 wk after symptoms disappear. Overdosage: Symptoms: Topical Use: Excessive use can result to skin irritation, which usually disappears after discontinuation of therapy. Treatment: Accidental Ingestion: Daktarin Cream is intended for topical use, not for oral use. Should accidental oral ingestion of large quantities of Daktarin Cream occurs, an appropriate method of gastric emptying may be used if considered necessary. Contraindications: Hypersensitivity. Special Precautions: Avoid contact w/ the mucosa of the eyes. Interactions: Miconazole administered systemically is known to inhibit CYP3A4/2C9. Due to the limited systemic availability after topical application (see Pharmacology: Pharmacokinetics under Actions), clinically relevant interactions occur very rarely. In patients on oral anticoagulants eg, warfarin, caution should be exercised and the anticoagulant effect should be monitored. The effects and adverse effects of some other drugs (eg, oral hypoglycemic and phenytoin), when co-administered with miconazole, can be increased and caution should be exercised. Caution for Usage: Instructions for Use and Handling: To open the tube, unscrew the cap. Then pierce the seal of the tube with the pin on the top of the cap. Use in pregnancy: Daktarin Cream applied topically are minimally absorbed into the systemic circulation (bioavailability <1%). Although there is no evidence that miconazole is embryotoxic or teratogenic in animals, potential hazards of prescribing Daktarin Cream during pregnancy should always be weighed against the expected therapeutic benefits. Use in lactation: Topically applied miconazole is minimally absorbed into the systemic circulation and it is not known whether miconazole is excreted in human breast milk. Caution should be exercised when using topically applied miconazole products during lactation.