Dosage / Direction for Use:
Adult & childn ≥7 yr one 650 mg tab once daily or bid. Pregnant & lactating women one 650 mg tab tid.
Administration:
Should be taken with food.
Contraindications:
Hypersensitivity. Severe hypercalcemia & hypercalciuria, hypervitaminosis D, hyperparathyroidism, severe kidney failure, osteoporosis due to immobility & decalcifying tumors. Patients w/ ventricular fibrillation. Patients on cardiac glycosides.
Special Precautions:
May precipitate arrhythmia. Potential constipation. Monitor blood levels & urinary Ca excretion. Increased incidence of prostate cancer. Patients w/ kidney impairment, cardiac disease associated w/ hypercalcemia eg, sarcoidosis. Avoid in patients w/ Ca-containing kidney stones or history of renal calculi. Milk-alkali syndrome.
Side Effects / Adverse Reactions:
GI irritation, constipation, bloating, flatulence, nausea & headache. Hypercalcemia on patients w/ chronic kidney failure.
Interactions:
Enhanced effects of digitalis glycosides. Risk of milk-alkali syndrome w/ thiazide diuretics. Decreased bioavailability of atenolol. May reduce absorption of Fe & Zn. Reduced absorption w/ alcohol, Al-containing compounds, mineral oil, stimulant laxatives (prolonged use), corticosteroids, foods rich in oxalic acid or phytic acid. May reduce serum levels w/ anticonvulsants. Biphosphonates, fluoride, some fluoroquinolones & tetracyclines, levothyroxine, phenytoin, aspirin, bismuth subcitrate, Ca-channel blocker & cefpodoxime, caffeine.