Administration :
May be taken with or without food.
Contraindications :
Phenylephrine-Chlorpheniramine (Bronchofen) should not be taken by asthmatic patients or by patients with known hypersensitivity to any of the active ingredients. It should not be administered concurrently with monoamine oxidase inhibitors or within 14 days of stopping such treatment.
Phenylephrine-Chlorpheniramine (Bronchofen) is contraindicated in patients with history of hypersensitivity to the active ingredients, in coronary artery disease, hypertension, hyperthyroidism, hyperexcitability, acute asthma attacks, tumor of the adrenal gland (pheochromocytoma) narrow-angle glaucoma and severe liver function impairment. It should be used with great caution by individuals with history of asthma, high blood pressure, diabetes, thyroid disease, glaucoma and enlargement of the prostate gland.
Special Precautions :
As chlorpheniramine maleate may cause drowsiness and sedation, patients must avoid engaging in activities which require mental alertness.
Phenylephrine, should be given with great caution in patients with diabetes mellitus. Safety in pregnancy and lactation has not been established.
Dosage / Direction for Use:
Syr Childn ≥12 yr 7.5 mL, 7-12 yr 5 mL, 2-6 yr 2.5 mL. Drops Childn 1-2 yr 1-1.25 mL, 6-12 mth 0.75-1 mL, 1-6 mth 0.5-0.75 mL. All doses to be taken tid-qid.
Side Effects / Adverse Reactions:
Dizziness. Chlorphenamine maleate: Sedation. Phenylephrine: Tremors & increase in BP; mild GI & CNS disturbance.
Interactions:
May increase sedating effects of CNS depressants eg, antipsychotics, anxiolytic sedatives, opioid analgesics, hypnotics, barbiturates & alcohol. Phenylephrine: Increased risk for toxicity w/ other sympathomimetics (eg, epinephrine); MAOIs (eg, sertraline, amitriptyline, imipramine); may decrease effect w/ adrenergic receptor blockers (eg, propranolol, phenothiazine, phentolamine).